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Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty

Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 177-180 doi: 10.1007/s11684-009-0021-x

Abstract: To evaluate the mechanism of vascular endothelial growth factor (VEGF) on the prevention of restenosisangioplasty, the recombinant adenovirus vector containing hVEGF cDNA was constructed and transfected into vascularsmooth muscle cells (VSMC) .Then, the VSMC and human umbilical vein endothelial cells (HUVEC) were divided into control group, H

Keywords: vascular endothelial growth factors     restenosis     reactive oxygen species     endothelial cells     vascular smooth    

Role of nitric oxide in biological effects of vascular endothelial growth factor

Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 284-286 doi: 10.1007/s11684-009-0062-1

Abstract: To evaluate the role of nitric oxide in the biological effects of vascular endothelial growth factor(VEGF) and the possible mechanism of VEGF, the cultured vascular endothelial cells of rabbit aorta wereThe absorbance () value of vascular endothelial cells and the levels of prostaglandin (PGI), endothelinendothelial cells and that L-NAME could inhibit the effect of VEGF partially.endothelial cells by VEGF.

Keywords: vascular endothelial growth factor     nitric oxide     N-nitro-L-arginine methyl ester     vascular endothelialcells    

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 403-409 doi: 10.1007/s11684-017-0522-y

Abstract: TFPI is expressed by endothelial and smooth muscle cells in the vasculature.However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascularPlasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelialcells and cells of hematopoietic origin) mice.

Keywords: arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth musclecells    

CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 204-211 doi: 10.1007/s11684-016-0443-1

Abstract: carbohydrate epitope (glycotope) functionally involved in blood spread and liver metastasis of cancer cellsby mediating the adhesion of cancer cells to endothelial cells and hepatocytes, respectively.The purified scFv can bind to the natural CD176 expressed on the surface of cancer cells.Furthermore, the CD176 scFv inhibits the adhesion of CD176+ cancer cells to endothelialcells and hepatocytes.

Keywords: CD176     Thomsen-Friedenreich antigen     scFv     cancer     therapy     adhesion     metastasis    

Effect of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved

Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 225-228 doi: 10.1007/s11684-010-0003-z

Abstract: bradykinin-B2 receptor as well as the possible involved signal transduction pathways in cultured rat aortic vascularsmooth muscle cells (VSMCs).Cells after 4–6 passages were used in the experiment.

Keywords: bradykinin     vascular smooth muscle cells     signal transduction pathways    

Changes in Lipoprotein Lipase in the Heart Following Diabetes Onset Review

Chae Syng Lee, Yajie Zhai, Brian Rodrigues

Engineering 2023, Volume 20, Issue 1,   Pages 19-25 doi: 10.1016/j.eng.2022.06.013

Abstract: To then move LPL to the endothelial cell (EC) lumen, glycosylphosphatidylinositol-anchored high-densitylipoprotein-binding protein 1 (GPIHBP1) attaches to interstitial LPL and transfers it to the vascularmoderate diabetes, with the reduction in glucose utilization, the heart increases its LPL activity at the vascularThis coincides with the loss of a cardioprotective growth factor—namely, vascular endothelial growth

Keywords: Cardiac metabolism     Lipoprotein lipase     Heparanase     Vascular endothelial growth factor     Diabetic cardiomyopathy    

Pluripotent stem cells exhibiting similar characteristics can be isolated from human fetal bone marrow

FANG Baijun, SONG Yongping, LIN Quande, ZHAO Chunhua, SHI Mingxia

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 185-191 doi: 10.1007/s11684-007-0035-1

Abstract: population derived from human fetal bone marrow (BM), termed here Flk1CD34 postembryonic pluripotent stem cellsinto the epithelium of liver, lung, gut, as well as the hematopoietic and endothelial lineages after, derma, kidney, and fat and then analyzed the characteristics and function of these stem cells.Morphologically, these cells were fibroblast-like and the doubling time was about 30 h.cells and hepatocytes.

Keywords: endothelial     phenomenon     ectodermal     Flk1CD34 postembryonic     irradiated non-obese    

Construction of eukaryotic expression vector of human arresten gene and its secreted expression in HEK 293 cells

Wei LI PhD , Siming GUAN MM , Zifang SONG PhD , Qichang ZHENG PhD , Jun XIONG PhD , Dan SHANG PhD , Xiaogang SHU PhD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 297-302 doi: 10.1007/s11684-009-0058-x

Abstract: of human arresten gene was constructed and its secretive expression human embryonic kidney (HEK 293) cellsThe recombinant plasmid was subsequently transfected into HEK 293 cells with LipofectAMINETM2000 ReagentRT-PCR revealed that the mRNA of the target gene was transcribed in the transfected HEK 293 cells.(MTT) assay was carried out to assess their effect on the proliferation of human umbilical vein endothelialumbilical vein endothelial cells .

Keywords: angiogenesis inhibitor     arresten     eukaryotic expression     HEK 293 cells     endothelial cells    

Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 136-140 doi: 10.1007/s11684-009-0029-2

Abstract: this study was to investigate the effects of resistin on insulin signaling in human umbilical vein endothelialcells (HUVECs).Akt and endothelial nitric oxide synthase (eNOS) phosphorylation levels of endothelial cells under basalcells under insulin stimulated conditions ( < 0.05 control).cells.

Keywords: resistin     endothelium     nitric oxide     endothelial nitric oxide synthase     Akt-binding protein     mouse    

Emerging roles of podoplanin in vascular development and homeostasis

Yanfang Pan,Lijun Xia

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 421-430 doi: 10.1007/s11684-015-0424-9

Abstract: PDPN) is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelialcells (LECs) in the vascular system and fibroblastic reticular cells (FRCs) in lymph nodes.is required to initiate and maintain separation of blood and lymphatic vessels and to stabilize high endothelialIn the vascular system, normal expression of PDPN at the LEC surface requires transcriptional activationThis review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid

Keywords: podoplanin     CLEC-2     Prox1     O-glycosylation     lymphatic vascular development and maintenance     lymphoid    

Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2 in breast cancer

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 164-170 doi: 10.1007/s11684-009-0038-1

Abstract: epithelial-mesenchymal transition (EMT) is regarded as the mechanistic basis for the behavior of cancer cellsThe expressions of E-cadherin (E-Cad), N-cadherin (N-Cad), vascular endothelial cell growth factor (VEGF

Keywords: epithelial-mesenchymal transition     vascular endothelial cell growth factor     matrix metalloproteinase-9    

Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate

WU Jun, LIN Jinchao, HE Zhaochu, OU Biru, GUO Haisen

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 356-358 doi: 10.1007/s11684-007-0068-5

Abstract: The effect of hyperlipidemia and inflammation on endothelial functions was studied.In the 20th week, serum lipid level and NO levels were measured, and the expression of vascular cellgroup, hyperlipidemia rats showed lower levels of NO and ncreases in leukocyte accumulation on the endothelialsurface, also stronger and more extensive endothelial expression of VCAM-1.In fenofibrate-treated group, the expression of VCAM-1 and leukocyte accumulation on the endothelial

Keywords: endothelial     16-week treatment     leukocyte accumulation     mg/kg     NO    

Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium

Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 638-643 doi: 10.1007/s11684-021-0831-z

Abstract: addition to affecting the lungs, COVID-19 can be a severe systemic inflammatory disease that is related to endothelialWe are calling for closer attention to endothelial dysfunction in COVID-19 not only for fully revealing

Keywords: COVID-19     endothelial dysfunction     inflammation reaction     cytokine storm    

Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 323-331 doi: 10.1007/s11684-008-0062-6

Abstract: Hypertension is characterized by vascular smooth muscle constriction and vascular remodeling involvingEvidence for the role of CAS in the regulation of vascular smooth muscle contractility is presented.These new findings establish the important role of CAS in the modulation of vascular smooth muscle functions

Keywords: Contraction stimulation     phosphatase-proline     molecular structure     discovered     hypertension    

Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction

LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 196-199 doi: 10.1007/s11684-007-0037-z

Abstract: The aim of this paper was to investigate the effects of resistin on human umbilical vein endothelialcells (HUVECs), and to explore its role and mechanism of action in atherosclerosis.

Keywords: endothelial     resistin stimulation     Incubation     pathogenesis     dysfunction    

Title Author Date Type Operation

Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty

Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU

Journal Article

Role of nitric oxide in biological effects of vascular endothelial growth factor

Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,

Journal Article

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Journal Article

CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Journal Article

Effect of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved

Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,

Journal Article

Changes in Lipoprotein Lipase in the Heart Following Diabetes Onset

Chae Syng Lee, Yajie Zhai, Brian Rodrigues

Journal Article

Pluripotent stem cells exhibiting similar characteristics can be isolated from human fetal bone marrow

FANG Baijun, SONG Yongping, LIN Quande, ZHAO Chunhua, SHI Mingxia

Journal Article

Construction of eukaryotic expression vector of human arresten gene and its secreted expression in HEK 293 cells

Wei LI PhD , Siming GUAN MM , Zifang SONG PhD , Qichang ZHENG PhD , Jun XIONG PhD , Dan SHANG PhD , Xiaogang SHU PhD ,

Journal Article

Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Journal Article

Emerging roles of podoplanin in vascular development and homeostasis

Yanfang Pan,Lijun Xia

Journal Article

Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2 in breast cancer

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Journal Article

Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate

WU Jun, LIN Jinchao, HE Zhaochu, OU Biru, GUO Haisen

Journal Article

Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium

Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang

Journal Article

Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Journal Article

Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction

LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi

Journal Article